Research progress on the dermatomyositis specific autoantibodies and malignancy associated dermatomyositis
10.11817/j.issn.1672-7347.2023.220594
- VernacularTitle:皮肌炎自身特异性抗体与皮肌炎相关性恶性肿瘤的研究进展
- Author:
Yue XU
1
;
Yang YANG
;
Songqing FAN
Author Information
1. 中南大学湘雅二医院病理科,长沙 410011
- Keywords:
dermatomyositis;
specific autoantibody;
malignant tumors;
migration inhibitory factor-2;
nuclear matrix protein-2;
transcription intermediary factor 1-γ;
small ubiquitin-like modifier activating enzyme
- From:
Journal of Central South University(Medical Sciences)
2023;48(12):1890-1898
- CountryChina
- Language:Chinese
-
Abstract:
Dermatomyositis(DM)is an autoimmune disease often complicated with malignant tumors.More than 50%of DM patients have myositis specific autoantibodies in their bodies.DM specific autoantibodies[including anti-migration inhibitory factor(Mi)-2 antibody,anti-nuclear matrix protein(NXP)-2 antibody,anti-transcription intermediary factor(TIF)1-γ antibody,and anti-small ubiquitin like modifier activating enzyme(SAE)antibody]play important roles in the pathogenesis of malignancy associated DM.Revealing the role of DM specific autoantibodies in the development of malignant tumors in DM patients can provide important evidence for accurately assessing the risk of developing malignant tumors in DM patients,and also provide new ideas for clinical diagnosis of DM and precise treatment.
