Research progress regarding CYP3A gene family in gastric cancer
10.11817/j.issn.1672-7347.2023.230150
- VernacularTitle:CYP3A基因家族在胃癌中的研究进展
- Author:
Qi JIA
1
;
Qingsong DING
;
Kangmei SHAO
;
Jianzhong DANG
;
Fan ZHANG
Author Information
1. 兰州大学第二临床医学院,兰州 730030
- Keywords:
cytochrome P450;
cytochrome P450 3A;
cytochrome P450 3A4;
gastric cancer;
tumor;
drug metabolizing enzymes
- From:
Journal of Central South University(Medical Sciences)
2023;48(12):1874-1881
- CountryChina
- Language:Chinese
-
Abstract:
Cytochrome P450 family 3 subfamily A(CYP3A),a major member of cytochrome P450(CYP)family,is one of the most important drug metabolizing enzymes in human.CYP3A includes 4 gene subtypes(CYP3A4,CYP3A5,CYP3A7,and CYP3A43),which is involved in 60%of drug metabolism in the human.It is not only widely distributed in normal tissues,but also significantly overexpressed in various tumor tissues.Recently,CYP3A has attracted great attention due to its involvement in the progression from chronic atrophic gastritis to gastric cancer,as well as the differential metabolism and resistance of chemotherapeutic drugs.Targeting CYP3A gene mediated-prodrug provides new ideas for the treatment of gastric cancer and is expected to become a new target for the diagnosis and treatment of gastric cancer.
