Role of copper and its complexes in cardiovascular diseases
10.11817/j.issn.1672-7347.2023.230159
- VernacularTitle:铜及其复合物在心血管疾病中的作用
- Author:
Wenjun ZHU
1
;
Yiyue ZHANG
;
Xiuju LUO
;
Jun PENG
Author Information
1. 中南大学湘雅药学院药理学系,长沙 410078
- Keywords:
copper;
cardiovascular diseases;
copper-based enzymes;
copper chaperones;
copper transporters;
copper complexes
- From:
Journal of Central South University(Medical Sciences)
2023;48(11):1731-1738
- CountryChina
- Language:Chinese
-
Abstract:
Copper is a trace element essential for the maintenance of normal physiological functions in cardiovascular system,and its transport and metabolisms are regulated by various copper proteins such as copper-based enzymes,copper chaperones and copper transporters.The disturbance of copper level or abnormal expression of copper proteins are closely associated with the development of cardiovascular diseases such as atherosclerosis,hypertension,ischemic heart disease,myocardial hypertrophy and heart failure.Thus,intervention of copper ion signaling pathways is expected to be an effective measure for treating cardiovascular diseases.Some copper complexes,such as trientine,copper-aspirinate complex and copper(Ⅱ)diethyldithiocarbamate,have been found to play a role in the prevention and treatment of cardiovascular diseases and possess potential prospects.Exploring the role of copper in maintaining normal cardiovascular status and the potential application of copper complexes in the treatment of cardiovascular diseases may lay a foundation for finding new targets for prevention and treatment of various cardiovascular diseases,and provide new ideas for clinical treatment of cardiovascular diseases.
