Exploration of Thoughts and Possible Therapeutic Mechanism of Treating Male Infertility from the Perspective of Spleen and Kidney by Regulating Intestinal Flora
10.13359/j.cnki.gzxbtcm.2024.03.037
- VernacularTitle:基于调节肠道菌群从脾肾论治男性不育症的思路及可能机制探讨
- Author:
Nian-Wen HUANG
1
;
Bin WANG
;
Ji-Sheng WANG
;
Huan-Zhou BI
;
Juan-Long FENG
;
Long-Ji SUN
;
Hai-Song LI
Author Information
1. 北京中医药大学东直门医院,北京 100007
- Keywords:
male infertility;
intestinal flora;
tonifying the kidney and strengthening the spleen;
inflammatory factors;
oxidative stress;
psychological stress;
exploration of thoughts
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2024;41(3):776-781
- CountryChina
- Language:Chinese
-
Abstract:
Based on the literature study,the thoughts and possible therapeutic mechanism in treating male infertility from the perspective of spleen and kidney by regulating intestinal flora were explored.Disturbance of intestinal flora is one of the important factors leading to the development of male infertility,and the spleen and kidney have certain similarities to intestinal flora in the physiological function and pathological changes.Moreover,tonifying the kidney and strengthening the spleen can regulate the intestinal flora by fostering the growth of beneficial bacteria,inhibiting the reproduction of pathogenic bacteria,and protecting the barrier of the intestinal mucosa.Therefore,the possible therapeutic mechanisms in treating male infertility with the prescriptions for tonifying the kidney and strengthening the spleen to regulate intestinal flora are as follows:inhibiting the expression of inflammatory factors to reduce the inflammatory reaction of testicular tissues;improving the antioxidant capacity to alleviate the damage of spermatozoa caused by oxidative stress,and improving the bad mood to alleviate the impact of psychological stress on the reproductive system.The exploration of the thoughts for treating male infertility from the perspective of spleen and kidney by regulating intestinal flora may provide a new entry point for modern Chinese medicine clinical treatment of male infertility.
