Research progress in clinical application and mechanism of Sijunzi Decoction in the treatment of gastric cancer
10.3760/cma.j.cn115398-20230307-00090
- VernacularTitle:四君子汤治疗胃癌的临床应用与机制研究进展
- Author:
Jingtao ZHAO
1
;
Bo NING
;
Meng XIAO
;
Yue QIN
;
Yanan LI
;
Qiuyan YANG
;
Haijuan XIAO
Author Information
1. 陕西中医药大学2021级硕士研究生，咸阳 712046
- Keywords:
Si Jun Zi Tang;
Gastric cancer;
Clinical application;
Mechanism study;
Research progress;
Review
- From:
International Journal of Traditional Chinese Medicine
2024;46(3):395-399
- CountryChina
- Language:Chinese
-
Abstract:
As a classic prescription for invigorating spleen and replenishing qi, Sijunzi Decoction has a good clinical efficacy in the treatment of gastric cancer. It can improve chemotherapy resistance, reduce the toxic and side effects of chemotherapy, promote postoperative recovery, enhance immunity, improve the nutritional status of patients, improve the quality of life of patients and prevent precancerous lesions. Network pharmacology studies have shown that Sijunzi Decoction exerts anti-gastric cancer effects through multiple active ingredients, multiple targets and multiple pathways, and quercetin may be the main active component in Sijunzi Decoction to exert anti-gastric cancer effects. The main mechanisms of Sijunzi Decoction in the treatment of gastric cancer include regulating the expression of cell cycle and apoptosis-related gene proteins, and inhibiting the proliferation, migration, invasion and gastric cancer stem cell characteristics of gastric cancer cells.
