Clinical study on Xiaosheng Powder ultrasonic nebulization combined with meibomian gland massage for the patients with meibomian gland dysfunction dry eye and pattern of liver depression and Yin deficiency
10.3760/cma.j.cn115398-20221115-00203
- VernacularTitle:逍生散超声雾化联合睑板腺按摩治疗睑板腺功能障碍型干眼肝郁阴虚证临床研究
- Author:
Zhifang ZHANG
1
;
An YANG
;
Like XIE
;
Xinqi KUANG
Author Information
1. 中国中医科学院眼科医院眼科，北京 100040
- Keywords:
Xerophthalmia;
Meibomian gland dysfunction;
Xiaosheng Powder;
Atomization;
Meibomian gland massage;
Syndrome of liver depression and Yin deficiency
- From:
International Journal of Traditional Chinese Medicine
2024;46(2):181-185
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy of Xiaosheng Powder ultrasonic nebulization combined with meibomian gland massage in treating liver depression and Yin deficiency pattern of meibomian gland dysfunction dry eye.Methods:Randomized controlled trial. From March 2021 to September 2021, a total of 50 patients (100 eyes) diagnosed with meibomian gland dysfunction dry eye of the liver depression and Yin deficiency pattern at the Ophthalmology Hospital of China Academy of Chinese Medical Sciences were selected. They were randomly divided into two groups using a random number table, with 25 patients (50 eyes) in each group. The control group received 0.1% sodium hyaluronate eye drops combined with meibomian gland massage, while the treatment group received Xiaosheng Powder nebulization combined with meibomian gland massage. Both groups were treated for 4 weeks. Before and after treatment, the tear film break-up time (BUT), Schirmer I test (SIT), corneal fluorescein staining (FL) scores, TCM symptom scores, and meibomian gland function scores were observed and evaluated. Adverse reactions were recorded.Results:After treatment, the treatment group exhibited statistically significant improvements compared to the control group in the following aspects: BUT was significantly longer in the treatment group (t=8.76, P<0.01); SIT values were significantly higher in the treatment group ( t=6.18, P<0.01); FL scores, TCM symptom scores and meibomian gland function scores were significantly lower than in the treatment group ( t values were 2.19, 5.36 and 12.09, P<0.01). The total effective rate in the treatment group was 96.0% (24/25), while in the control group, it was 68.0% (17/25), and the difference between the two groups was statistically significant ( χ2=4.88, P=0.027). Conclusion:The combination of Xiaosheng Powder ultrasonic nebulization and meibomian gland massage is effective in improving the clinical symptoms of patients with meibomian gland dysfunction dry eye of the liver depression and Yin deficiency pattern. Furthermore, this approach is considered safe and efficient.
