Discussion on scientific connotation of "cold coagulation and blood stasis" for endometriosis pathogenesis based on iron overload
10.3760/cma.j.cn115398-20230209-00135
- VernacularTitle:基于铁过载探讨子宫内膜异位症“寒凝血瘀成癥”病机的科学内涵
- Author:
Yuejian ZHANG
1
;
Wenbai QU
;
Conglu SUI
;
Yanan GUO
;
Tiantian HE
;
Mengping YANG
;
Wenjuan ZHANG
;
Xiaona MA
Author Information
1. 北京中医药大学第三临床医学院2021级博士研究生，北京 100029
- Keywords:
Endometriosis;
Cold coagulation and blood stasis;
Iron overload;
Ferroptosis;
Iron homeostasis
- From:
International Journal of Traditional Chinese Medicine
2023;45(12):1473-1477
- CountryChina
- Language:Chinese
-
Abstract:
This article analyzed the specific path of iron overload affecting EMT "blood countercurrent cell survival/adhesion/invasion/angiogenesis ectopic lesions" from the three aspects of mediating NF-κB and inflammatory reaction, stimulation of abnormal activation of macrophages, and induction of oxidative stress injury; introduced the theoretical connotation of the pathogenesis of "cold coagulation and blood stasis", and briefly described the progress of the pathogenesis of EMT from the perspective of "blood out of menstruation - injury caused by cold pathogenic factors - cold coagulation and blood stasis - long-term accumulation syndrome"; based on the mutual confirmation of "menstruation countercurrent - iron overload microenvironment - cell survival/adhesion/invasion/angiogenesis - ectopic focus" and "blood out of menstruation - cold pathogen injury - cold coagulation and blood stasis - chronic accumulation syndrome", it was believed that starting from iron overload could tap the scientific connotation and microscopic materials of the pathogenesis of "cold coagulation and blood stasis" in EMT, so as to provide new directions and theoretical references for the research of the pathogenesis of EMT and the mechanism of drugs.
