Discussion on the mechanism of Jiangtang Xiaoke Granules for diabetes mellitus based on network pharmacology and molecular docking
10.3760/cma.j.cn115398-20220612-00144
- VernacularTitle:基于网络药理学与分子对接技术探讨降糖消渴颗粒治疗糖尿病作用机制
- Author:
Wenhua ZHANG
1
;
Weiyu JIA
;
Mingxue ZHOU
;
Shuwen ZHANG
;
Churan WANG
;
Yijia JIANG
;
Yanbing GONG
;
Sihua GAO
Author Information
1. 北京中医药大学东直门医院肾病内分泌科，北京 100700
- Keywords:
Diabetes mellitus;
Jiangtang Xiaoke Granule;
Network pharmacology;
Molecular docking simulation;
Molecular mechanisms of pharmacological action (TCD)
- From:
International Journal of Traditional Chinese Medicine
2023;45(10):1293-1299
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To predict the possible targets and signaling pathways of Jiangtang Xiaoke Granules in the treatment of diabetes mellitus (DM) using computer network pharmacology and molecular docking technology.Methods:The active components and targets of Jiangtang Xiaoke Granules were collected by ETCM; the targets of DM were searched from the databases of DisGeNET and GeneCards, and the intersections of the two were taken to draw a Venny diagram; String database was used for gene transformation and network interaction analysis; the network diagram was constructed with Cytoscape3.6.0; the predicted results were supported by molecular docking technology; GO and KEGG analysis was performed through Metascape database.Results:A total of 128 active components of Jiangtang Xiaoke Granules were screened, with 607 corresponding targets, 1 240 DM related targets, and 53 core targets. Molecular docking showed that the active components had good binding energy with the core targets. GO analysis yielded 46 functional items and KEGG analysis yielded 15 pathways.Conclusion:Jiangtang Xiaoke Granules regulate glucose homeostasis by participating in a variety of biological processes through multiple components, and multiple targets, including affecting lipids and atherosclerosis, Alzheimer disease, AMPK signaling pathway, Apelin signaling pathway, and glucagon signaling pathway.
