Research progress on the mechanism of microRNA regulation of cisplatin resistance in ovarian cancer
10.3760/cma.j.cn371439-20231109-00030
- VernacularTitle:微RNA调控卵巢癌顺铂耐药的机制研究进展
- Author:
Yan GONG
1
;
Honglei CHEN
Author Information
1. 武汉大学中南医院病理科，武汉 430071
- Keywords:
Ovarian neoplasms;
MicroRNAs;
Cisplatin;
Drug resistance, neoplasm
- From:
Journal of International Oncology
2024;51(3):186-190
- CountryChina
- Language:Chinese
-
Abstract:
Cisplatin resistance is an important factor in the poor treatment effect of ovarian cancer patients. MicroRNA (miRNA) can regulate cellular structural molecules, DNA repair, cell cycle, apoptosis and Wnt/β-catenin signaling pathway, autophagy, methylation and cancer stem cell, which are involved in the regulation of cisplatin resistance in ovarian cancer. Further understanding the mechanism of miRNA regulation of cisplatin resistance in ovarian cancer will help find new treatment options to optimize existing treatment plans and improve efficacy.
