Research progress of myeloid-derived suppressor cells in tumor angiogenesis
10.3760/cma.j.cn371439-20230227-00006
- VernacularTitle:髓源性抑制细胞在肿瘤血管生成中的研究进展
- Author:
Xiaodi LIU
1
;
Jianfei SU
;
Jingxian ZHANG
;
Xueqin WEI
;
Yingjie JIA
Author Information
1. 天津中医药大学第一附属医院肿瘤科 国家中医针灸临床医学研究中心，天津 300381
- Keywords:
Myeloid-derived suppressor cells;
Tumor microenvironment;
Angiogenesis
- From:
Journal of International Oncology
2024;51(1):50-54
- CountryChina
- Language:Chinese
-
Abstract:
As a kind of immunosuppressive cells, myeloid-derived suppressor cells (MDSCs) are an important component of the immune microenvironment. MDSCs play a significant role in promoting tumor immune escape. In addition, non-immunological functions such as promoting angiogenesis can also promote tumor development with the deepening of research. MDSCs can promote tumor angiogenesis directly through vascular endothelial growth factor signaling pathway, or promote tumor growth and angiogenesis by secreting cytokines such as matrix metalloprotein-9, basic fibroblast growth factor, angiogenic peptide Bv8, platelet derived growth factor, exosomes, or interacting with other cells. Exploring the expansion, activation, recruitment and angiogenesis mechanism of MDSCs will provide new ideas for regulating the individualized diagnosis and treatment based on targeted MDSCs.
