Risk factors and predictors of immune-related adverse events induced by immune checkpoint inhibitors

VernacularTitle:免疫检查点抑制剂相关不良反应的危险因素与预测因素
Author: Panpan JIAO ¹ ; Lijuan XUE ; Juan ZHAN
Author Information

1. 厦门大学附属中山医院肿瘤内科，厦门　361004
Keywords: Immune checkpoint inhibitors; Drug-related side effects and adverse reactions; Risk factors; Predictors
From: Journal of International Oncology 2023;50(12):739-744
CountryChina
Language:Chinese
Abstract: Immune checkpoint inhibitors are commonly used in clinical practice and have achieved good efficacy, but immune-related adverse events (irAEs) are often unpredictable and may lead to serious clinical consequences. Risk factors for irAEs include gender, body mass index, tumor class, drug type, pre-existing autoimmune disease, and tumor mutational burden; predictors are mainly immune cells, cytokines and chemokines, autoantibodies, genome, and gut microbes. By further investigating the mechanisms, risk factors and predictors for the occurrence of irAEs, guidance for the clinical prediction and management of irAEs is supposed to be provided.