Value of extracellular vesicle DNA as an indicator of tumor liquid biopsy molecules

VernacularTitle:细胞外囊泡DNA作为肿瘤液体活检分子的指标价值
Author: Shuhui YIN ¹ ; Rong WEN ; Shufang MIAO
Author Information

1. 内蒙古自治区国际蒙医医院临床检验中心，呼和浩特　010020
Keywords: Extracellular vesicles; Neoplasms; DNA
From: Journal of International Oncology 2023;50(11):668-671
CountryChina
Language:Chinese
Abstract: Extracellular vesicle (EV) is widely distributed and fully involved in the regulation of various aspects of cellular physiology. As active carriers of molecular biomarkers and mediators of intercellular communication, EV is involved in the occurrence, development, metastasis, drug resistance and other links of tumors. The EV, which can be obtained from a variety of body fluids and are highly homologous to tissues, plays an important role in the maintenance of cell homeostasis and the exchange of substances and information between cells, thus becoming an ideal biomarker for tumor diagnosis and treatment. In the emerging liquid biopsy application, EV DNA can be used as a molecular marker for the diagnosis and prognosis evaluation of many kinds of tumors, and it is the most potential molecular marker of liquid biopsy in the field of tumor diagnosis and treatment.