Role of ABRACL in the occurrence and development of malignant tumors

VernacularTitle:ABRACL在恶性肿瘤发生发展中的作用
Author: Tongtong YE ¹ ; Zeyu WU ; Wenyi XI ; Zhiwei WANG ; Xiaochun JIANG ; Chenhui ZHAO
Author Information

1. 皖南医学院第一附属医院神经外科，芜湖　241000
Keywords: Neoplasms; Carcinogenesis; Cytoskeleton; ABRACL
From: Journal of International Oncology 2023;50(9):544-547
CountryChina
Language:Chinese
Abstract: The ABRACL protein, the regulator of actin and cell motility, belongs to the HSPC280 family, and its conserved hydrophobic groove can interact with other proteins to facilitate actin motility and cellular activity. ABRACL is upregulated in tumor tissues and is closely linked with the proliferation and migration of tumor cells. A deeper understanding of the role of ABRACL in tumorigenesis and development may provide new ideas and insights for ABRACL to prevent or reverse tumor progression.