Relationships between HER2 protein expression and imaging features in HER2 positive breast cancer patients
10.3760/cma.j.cn371439-20221214-00101
- VernacularTitle:HER2阳性乳腺癌患者HER2表达水平与影像学特征的关系
- Author:
Chengtian FENG
1
;
Furong HUANG
;
Shiyu CAO
;
Jianyu WANG
;
Abiyasi NANDING
;
Yongdong JIANG
;
Juanying ZHU
Author Information
1. 浙江省嘉兴市妇幼保健院乳腺科，嘉兴 314000
- Keywords:
Breast neoplasms;
Receptor, erbB-2;
Ultrasonography;
Mammography
- From:
Journal of International Oncology
2023;50(9):527-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationships between the expression level of human epidermal growth factor receptor 2 (HER2) in HER2-positive breast cancer and the characteristics of ultrasound imaging and mammography.Methods:The imaging data of 486 patients with HER2-positive breast cancer treated in the Harbin Medical University Cancer Hospital from January 2014 to December 2021 were retrospectively collected. The relationships between the expression level of HER2 and the imaging features of breast ultrasound and mammography were analyzed.Results:49.38% (240/486) of HER2-positive breast cancer patients were HER2 2+, and 50.62% (246/486) of HER2-positive breast cancer patients were HER2 3+. The age of HER2 2+ patients [ (52.88±1.16) years] was older than the age of HER2 3+ patients [ (49.59±1.00) years], and there was a statistically significant difference ( t=18.07, P<0.001) . There was a statistically significant difference of menstrual status between HER2 2+ patients and HER2 3+ patients ( χ2=4.42, P=0.036) . There were statistically significant differences in the ultrasonography showed burr sign ( χ2=8.37, P=0.010) , posterior echo ( χ2=9.68, P=0.017) , axillary lymph node enlargement ( χ2=15.77, P<0.001) between HER2 2+ patients and HER2 3+ patients. There was a statistically significant difference in the mammography showed whether there were lumps between HER2 2+ patients and HER2 3+ patients ( χ2=15.81, P<0.001) . Conclusion:The expression level of HER2 in HER2-positive breast cancer patients is related to burr sign, posterior echo, and axillary lymph node enlargement shown by ultrasound, as well as lumps shown by mammography, which can provide certain information for clinical prediction of malignant degree of breast cancer, prognosis and individualized treatment plan.
