Research progress of Nrf2 in ovarian cancer
10.3760/cma.j.cn371439-20230525-00094
- VernacularTitle:Nrf2在卵巢癌中的研究进展
- Author:
Rong AN
1
;
Meihua LIU
;
Peichen WANG
;
Xiaohui WANG
Author Information
1. 兰州大学第一临床医学院，兰州 730000
- Keywords:
Ovarian neoplasms;
NF-E2-related factor 2;
Antineoplastic combined chemotherapy protocols;
Drug resistance, neoplasm
- From:
Journal of International Oncology
2023;50(8):493-497
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is an important transcription factor that regulates redox, lipid metabolism and protein dynamic balance, and plays an important role in protecting the body from oxidative stress damage. Recently, more and more studies have shown that Nrf2 is activated in ovarian cancer by various mechanisms to induce increased antioxidant enzymes, change sex hormone metabolism and induce downstream targets. Further studying the mechanism of Nrf2 in promoting the development of ovarian cancer, exploring its role in drug resistance and seeking new therapeutic targets can provide new ideas for the treatment of drug-resistant ovarian cancer.
