Mechanism of action and clinical significance of CST1 in the progression of gastric cancer
10.3760/cma.j.cn371439-20230308-00093
- VernacularTitle:CST1在胃癌进展中的作用机制及临床意义
- Author:
Huifang SHAO
1
;
Xuehong WANG
;
Yongfu LU
Author Information
1. 青海大学研究生院，西宁 810016
- Keywords:
Stomach neoplasms;
Cysteine protease inhibitor 1
- From:
Journal of International Oncology
2023;50(8):489-492
- CountryChina
- Language:Chinese
-
Abstract:
Cysteine protease inhibitor 1 (CST1) is a member of type 2 Cystatins superfamily, plays a key role in targeted regulation. CST1 is highly expressed in gastric cancer, promotes tumor cell migration and invasion by activating the epithelial-mesenchymal transformation pathway and Wnt pathway, and regulates tumor growth and progression in combination with the corresponding target genes of homeobox C10 and glutathione peroxidase 4. A deeper understanding of the role and function of CST1 in gastric cancer will help to further develop potential therapeutic targets and diagnostic and prognostic markers for gastric cancer.
