Mechanism of telomerase in affecting biological characteristics of gastric cancer
10.3760/cma.j.cn115396-20230802-00019
- VernacularTitle:端粒酶影响胃癌生物学特征的机制研究进展
- Author:
Yulu WANG
1
;
Junmin ZHU
;
Zhiyao HAN
;
Senhuan WANG
;
Youxi JIANG
;
Minmin ZHANG
;
Gang CHEN
Author Information
1. 兰州大学第二临床医学院，兰州 730030
- Keywords:
Stomach neoplasms;
Telomerase;
Behavior and behavior mechanisms
- From:
International Journal of Surgery
2024;51(1):66-72
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is one of the major diseases threatening human health, with a high incidence and a low early diagnostic rate. There are many bottlenecks encountered during its treatment. Consequently, improving the early diagnostic rate and exploring new therapeutic targets are currently urgent challenges that need to be addressed. Telomerase is undetectable in normal tissues, but it exhibits high specificity and sensitivity in most cancers and has a definite correlation with prognosis. It may serve as a serum tumor marker and prognostic indicator. Human telomerase reverse transcriptase (hTERT) gene polymorphism can regulate the susceptibility of people to gastric cancer, and affect the occurrence, development, proliferation and apoptosis of gastric cancer through its target gene. Substances such as resistin, visfatin, G-quadruplex and methylenedioxyaniline can affect the occurrence and development of gastric cancer by regulating telomerase expression. The mechanism by which hTERT regulates tumor invasion and metastasis is currently unclear, so elucidating its mechanism is of great significance.This paper will review the research progress of this mechanism in recent years.
