Advances on molecular testing for cervical lymph node metastasis of thyroid cancer
10.3760/cma.j.cn115396-20231116-00141
- VernacularTitle:甲状腺癌颈淋巴结转移分子检测的研究进展
- Author:
Baolin CHEN
1
;
Zhongliang YAN
;
Chengmin LUO
;
Yuxiang BAO
;
Xiaoming CHENG
;
Junyuan LYU
Author Information
1. 遵义医科大学附属医院普通外科，遵义 563099
- Keywords:
Thyroid neoplasms;
Lymph nodes;
Biopsy, needle;
Diagnosis
- From:
International Journal of Surgery
2024;51(1):48-53
- CountryChina
- Language:Chinese
-
Abstract:
Cervical lymph node metastasis in thyroid cancer is closely related to the disease recurrence and prognosis of patients. Accurate judgment of lymph node metastasis is vital for tumor stage and treatment in patients with thyroid cancer, which can effectively improve the prognosis of patients. However, preoperative detection of cervical lymph node metastasis is the key points and difficulties in individualized treatment of thyroid cancer. Currently, fine needle aspiration washout fluid thyroglobulin is often used to assess cervical lymph node metastasis of differentiated thyroid cancer preoperatively, and it has a higher diagnostic efficacy. The continuous exploration and application of tumor markers and emerging biomarkers have provided new perspectives for the preoperative diagnosis of lymph node metastasis in thyroid cancer. As a new non-invasive detection technique, liquid biopsy is convenient to obtain samples and has broad clinical application in early diagnosis of cervical lymph node metastasis of thyroid cancer. In addition, the analysis and application of liquid biopsy biomarkers will help the development of clinical diagnosis and treatment strategies, and provide the possibility of early precision therapy for thyroid cancer patients. This review summarizes current research surrounding the molecular markers related to cervical lymph node metastasis of thyroid cancer.
