Research progress in immune escape and immunotherapy of glioma
10.3760/cma.j.cn115396-20230906-00054
- VernacularTitle:脑胶质瘤的免疫逃逸及免疫治疗研究进展
- Author:
Xiaohu ZHAO
1
;
Xiaochen NIU
;
Hongming JI
;
Chunhong WANG
Author Information
1. 山西医科大学第五临床医学院，太原 030012
- Keywords:
Glioma;
Central nervous system;
Immunotherapy;
Immune escape;
Tumor microenvironment
- From:
International Journal of Surgery
2023;50(12):855-860
- CountryChina
- Language:Chinese
-
Abstract:
Glioma is the most common primary intracranial tumor. Despite surgical resection, radiation therapy, chemotherapy, and Tumor Treating Fields, the median survival period is still less than 21 months. In recent years, immunotherapy for glioma has become a research hotspot. The immune microenvironment of glioma plays an important role in immune escape, which is an important means of malignant progression. Exploring the immune escape mechanism of glioma, understanding the progress of immunotherapy, and extending the survival period of patients with glioma as much as possible are the major challenges facing glioma treatment. Therefore, this article reviews the new understanding of the immune system in the central nervous system, immune cells and immune escape in glioma, and immunotherapy for glioma, to help further understand the mechanism of glioma development and provide new ideas for immunotherapy.
