Research progress on animal models of diabetes and lower limb ischemia
10.3760/cma.j.cn115396-20230918-00068
- VernacularTitle:糖尿病及下肢缺血动物模型研究进展
- Author:
Hu LI
1
;
Tao DI
;
Yeerbao ZAIYING
;
Ye TIAN
Author Information
1. 新疆医科大学第一附属医院血管甲状腺外科，乌鲁木齐 830011
- Keywords:
Diabetes mellitus;
Disease models, animal;
Ischemia;
Methods
- From:
International Journal of Surgery
2023;50(11):783-787
- CountryChina
- Language:Chinese
-
Abstract:
Establishing appropriate animal models of diabetes is of great importance for gaining in-depth understanding of the pathogenesis of diabetes, conducting diagnosis, and developing novel therapeutic interventions. Exploring methods for treating limb ischemia and comprehending its clinical pathophysiological progression is a significant approach achieved through the use of animal models of lower limb ischemia. In recent years, with the rapid advancements of various techniques, the establishment of lower limb arterial ischemia models and diabetes models has made considerable progress. The establishment of these models carries vital implications for researching and comprehending the mechanisms underlying lower limb arterial ischemia and the impact of diabetes. Successfully and reliably preparing these two models is crucial for elucidating the pathogenesis, pathophysiology, and treatment of lower limb vascular lesions associated with diabetes. This paper provides an overview of the research on the establishment methods of a diabetic rat model of lower limb ischemia, covering the principles, methods, and relevant parameters of establishing a diabetic rat model and a lower limb ischemia model in diabetes.
