Research progress on the correlation between interferon-γ and atherosclerosis
10.3760/cma.j.cn115396-20230609-00167
- VernacularTitle:γ-干扰素与动脉粥样硬化的相关性研究进展
- Author:
Sen TIAN
1
;
Chen DUAN
;
Boru HUANG
;
Zhanfeng GAO
Author Information
1. 内蒙古医科大学附属医院血管外科，呼和浩特 010059
- Keywords:
Arteriosclerosis;
Interferons;
Inflammation;
Foam cells;
Mechanism of action
- From:
International Journal of Surgery
2023;50(11):762-765
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a chronic disease caused by thickening of the lining of the arteries, narrowing of the lumen or hardening of occlusion, and the incidence is increasing year by year. Studies have found that the inflammatory response is involved in different pathological processes in atherosclerosis. As an important inflammatory factor, interferon-γ participates in the occurrence and development of atherosclerosis by promoting endothelial cell damage, inducing foam cell formation, and promoting plaque formation and rupture. However, studies have shown that interferon-γ can also act on lipid receptors to inhibit the formation of foam cells, inhibit the proliferation of smooth muscle cells and protect against atherosclerosis.This article will review the effect of interfron-γ of atherosclerosis in occurence and development.
