Advanced in red blood cells and platelets as carriers for anti-tumor drug delivery
10.3760/cma.j.cn121382-20231229-00106
- VernacularTitle:红细胞和血小板作为载体用于抗肿瘤药物递送的研究进展
- Author:
Zhaoqing SHI
1
;
Shiman LU
;
Lin MEI
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Red blood cells;
Platelets;
Drug delivery systems;
Tumor therapy
- From:
International Journal of Biomedical Engineering
2024;47(1):33-38
- CountryChina
- Language:Chinese
-
Abstract:
Red blood cells and platelets are widely present in the blood. They are easily isolated from the blood and relatively stable in nature, making them an ideal drug delivery vehicle. In recent years, a large number of studies have been conducted to use red blood cells and platelets to deliver antitumor drugs and achieve efficient drug delivery. Red blood cells and platelets have shown excellent results in optimizing the in vivo behavior of drugs, increasing efficacy, and reducing the dose administered. In addition, its cell membrane can be used as a coating material to improve the properties of nanodrug delivery systems and achieve biomimetic functions while reducing the toxic side effects of nanoparticles. The characteristics and preparation methods of red blood cells and platelets and their membrane materials were introduced, and their diagnostic and therapeutic applications in antitumor drug delivery was looked forward.
