Research progress in calcium phosphate-based biomacromolecules antigen delivery system
10.3760/cma.j.cn121382-20230605-00514
- VernacularTitle:磷酸钙基生物大分子抗原递送系统的研究进展
- Author:
Fangxin XIONG
1
;
Zhangran DU
;
Yadi TENG
;
Min XUE
;
Weiying XUN
;
Zhongxiong FAN
;
Jinyao LI
Author Information
1. 新疆大学生命科学与技术学院，生物学国家级实验教学示范中心，新疆生物资源基因工程重点实验室，乌鲁木齐 830046
- Keywords:
Nanomaterials;
Calcium phosphate;
Antigen delivery system;
Biomacromolecules
- From:
International Journal of Biomedical Engineering
2023;46(5):466-475
- CountryChina
- Language:Chinese
-
Abstract:
Nanometer materials have attracted much attention in the nanomedical field due to their unique physicochemical properties. Calcium phosphate nanoparticles have many advantages, such as non-toxicity, unique biomolecular protection, good biodegradability, and good biocompatibility. It has been widely studied as an ideal delivery system for biomacromolecules. In this review paper, the synthesis methods of calcium phosphate nanoparticles were summarized, including the conventional hydrothermal/solvothermal method and the aqueous wet chemical precipitation method. Moreover, the ways of binding calcium phosphate nanoparticles to biomacromolecule antigens were discussed from the perspectives of covalent and non-covalent binding, and their application in biomacromolecule delivery systems was described. The above review comments have important reference value for understanding the potential and application prospects of calcium phosphate nanoparticles in nanomedicine.
