Effect of concentrated growth factors and lower-level laser therapy on alveolar bone atrophy after tooth extraction site in orthodontic patients
10.3760/cma.j.cn121382-20230513-00507
- VernacularTitle:富自体生长因子纤维蛋白和低能量激光治疗对正畸患者拔牙位点牙槽骨变化影响的比较
- Author:
Dongni LIU
1
;
Hongbin LI
;
Ronghua LI
Author Information
1. 天津市北辰医院口腔科，天津 300400
- Keywords:
Concentrated growth factors;
Low-level laser therapy;
Orthodontic treatment;
Cytokines;
Alveolar bone atrophy
- From:
International Journal of Biomedical Engineering
2023;46(5):420-426
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effects of concentrated growth factors (CGF) and lower-level laser therapy (LLLT) on alveolar bone changes at the extraction site in orthodontic patients.Methods:Twenty-one patients who underwent orthodontic treatment at the Department of Stomatology, Tianjin Beichen Hospital, from June 2020 to May 2022 were enrolled and randomly divided into the control group, LLLT group, and CGF group, with 7 patients in each group and 28 extraction sites. The control group received natural healing with tooth extraction (minimally invasive healing with tooth extraction). The LLLT group received diode laser treatment on the 1st, 2nd, and 7th days after minimally invasive tooth extraction (wavelength 808 nm, average output power 0.25 W, energy density 4 J/cm 2, spot area 0.28 cm 2), with each site irradiated for 20 seconds. After minimally invasive tooth extraction in the CGF group, immediately place the CGF membrane in the extraction socket. The changes in alveolar bone height and width before and after tooth extraction and bone density and bone contour after alveolar bone healing were measured. Meanwhile, the concentration changes of growth factors osteopontin (OPN) and transforming growth factor-β1 (TGF-β1) in gingival crevicular fluid at tooth extraction were measured and statistically analyzed. Results:Compared with the control group, the height and width of the alveolar bone at the tooth extraction wound in the LLLT group and CGF group decreased significantly (all P < 0.05). Compared with the LLLT group, the height and width of the alveolar bone at the tooth extraction wound in the CGF group decreased, and the differences were statistically significant (all P < 0.05). The bone contour score and bone density grading of the LLLT and CGF groups after tooth extraction wound healing were better than those of the control group (all P < 0.05). There was no statistically significant difference in bone contour score and bone density grading between the LLLT group and the CGF group after tooth extraction wound healing ( P > 0.05). At 1 and 6 months after tooth extraction, there was no statistically significant difference in the concentration of OPN in the gingival crevicular fluid at the extraction site among the control group, LLLT group, and CGF group (all P > 0.05). One month after tooth extraction, compared with the control group, the concentration of TGF-β1 in the gingival crevicular fluid of the tooth extraction wound increased in the LLLT group and the CGF group, and the differences were statistically significant (all P < 0.05). Six months after tooth extraction, there was no statistically significant difference in TGF-β1 concentration among the three groups (all P > 0.05). Conclusions:Both LLLT and CGF treatments can effectively reduce the height and width of alveolar bone in tooth extraction wounds, promote the recovery of alveolar bone contour and bone density in tooth extraction wounds and provide clinical data support for how to delay the atrophy of alveolar bone in tooth extraction wounds.
