Neuroprotective therapy for acute ischemic stroke in the era of endovascular therapy
10.3760/cma.j.issn.1673-4165.2024.01.010
- VernacularTitle:血管内治疗时代急性缺血性卒中的神经保护治疗
- Author:
Mengmeng WANG
1
;
Zhaoyang YAN
;
Lingyu ZHANG
;
Honghong JI
;
Pengfei WANG
Author Information
1. 山东第二医科大学，潍坊 261000
- Keywords:
Ischemic stroke;
Endovascular procedures;
Thrombectomy;
Neuroprotective agents;
Neuroprotection
- From:
International Journal of Cerebrovascular Diseases
2024;32(1):56-61
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, endovascular therapy has become the most important progress in the field of the treatment of acute ischemic stroke caused by large vessel occlusion. However, the vascular recanalization shown by imaging after endovascular treatment cannot fully translate into effective tissue reperfusion and functional outcome, a phenomenon known as "futile recanalization". Combined neuroprotective therapy after vascular recanalization is expected to reduce the occurrence of futile recanalization and improve the outcome of patients. This article briefly summarizes the main application progress of commonly used neuroprotective therapies in clinical practice (edaravone dexborneol, glucocorticoids, hypothermia, and remote ischemic conditioning). It explores the trend and direction of combining endovascular therapy and neuroprotective therapy for patients with acute ischemic stroke caused by large vessel occlusion, and provides further reference and suggestions for intervention measures after endovascular therapy.
