Lipoprotein-associated phospholipase A 2 and cognitive impairment in patients with cerebral small vessel disease
10.3760/cma.j.issn.1673-4165.2024.01.008
- VernacularTitle:脂蛋白相关磷脂酶A 2与脑小血管病患者的认知损害
- Author:
Sai YAO
1
;
Congcong YAN
;
Xue BAI
;
Wei JIN
Author Information
1. 河北北方学院研究生院，张家口 075000
- Keywords:
Cerebral small vessel diseases;
Cognition disorders;
1-Alkyl-2-acetylglycerophosphocholine esterase;
Phospholipases A 2
- From:
International Journal of Cerebrovascular Diseases
2024;32(1):45-49
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the incidence of cerebral small vessel disease (CSVD) has been increasing with the aging of the population, and the cognitive impairment caused by it has brought huge burden to patients and their families. As a novel inflammatory biomarker, lipoprotein-associated phospholipase A 2 (Lp-PLA 2) directly participates in the pathogenesis of cognitive impairment in patients with CSVD by regulating circulatory vascular injury and neuroinflammation, and is expected to become a predictive indicator and therapeutic target for CSVD.
