Murine models of cerebral cavernous malformations
10.3760/cma.j.issn.1673-4165.2023.11.012
- VernacularTitle:小鼠脑海绵状血管瘤模型
- Author:
Shiqi KUANG
1
;
Jing LIN
;
Lin CHEN
Author Information
1. 南华大学附属第二医院神经内科，衡阳 421000
- Keywords:
Hemangioma, cavernous, central nervous system;
Disease models, animal;
Mice;
Gene knockout
- From:
International Journal of Cerebrovascular Diseases
2023;31(11):868-874
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral cavernous malformations (CCMs) are the common cerebrovascular malformation. Its incidence was 0.16%-0.5%. CCM can exist in both sporadic and familial forms, with the latter being inherited in an autosomal dominant manner. Its pathogenesis is associated with mutations in the CCM1, CCM2, and CCM3 genes. The somatic mutations of these genes are the basis for the occurrence of brain lesions. In order to explore the pathogenesis of CCM and identify therapeutic targets, various CCM animal models have been developed, providing assistance for the study of the pathological and physiological mechanisms of CCM. However, each CCM model has its own advantages, disadvantages, and applicability. Mice are the most commonly used animals to model CCM. Therefore, this article summarizes the characteristics and research progress of current murine CCM models.
