Role of TREM2-mediated immunomodulation of microglia in ischemic stroke
10.3760/cma.j.issn.1673-4165.2023.10.009
- VernacularTitle:TREM2对小胶质细胞的免疫调控在缺血性卒中中的作用
- Author:
Sijie LIU
1
;
Wenhao ZHANG
;
Shiyi TANG
;
Lixuan ZHAN
Author Information
1. 广州医科大学附属第二医院神经内科，广州医科大学神经科学研究所，广州 510260
- Keywords:
Ischemic stroke;
Receptors, immunologic;
Membrane glycoproteins;
Microglia;
Phagocytosis;
Inflammation;
Neuroprotection
- From:
International Journal of Cerebrovascular Diseases
2023;31(10):773-778
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is a common neurological disorder that can lead to neuronal death and neurological dysfunction. Microglia is the main immune cells in the central nervous system, involved in post-stroke inflammation and tissue repair. Triggering receptor expressed on myeloid cells 2 (TREM2), a receptor expressed on the surface of microglia, plays a multifaceted role in neuronal survival and nerve repair after ischemic stroke, including promoting the phagocytosis of microglia, inhibiting excessive inflammatory response, maintaining the proliferation and survival of microglia, protecting neurons from damage, and promoting the recovery of nerve function. Therefore, elucidating the immunoregulatory mechanism of TREM2 on microglia after cerebral ischemia is of great significance for exploring new therapeutic directions for ischemic stroke.
