Role and mechanism of ferroptosis in ischemic brain injury
10.3760/cma.j.issn.1673-4165.2023.09.013
- VernacularTitle:铁死亡在缺血性脑损伤中的作用和机制
- Author:
Mengqi DONG
1
;
Xiang CAO
;
Yun XU
Author Information
1. 南京医科大学鼓楼临床医学院，南京 210008
- Keywords:
Ischemic stroke;
Brain ischemia;
Ferroptosis;
Signal transduction
- From:
International Journal of Cerebrovascular Diseases
2023;31(9):711-716
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a cell death mode characterized by iron-dependent and excessive accumulation of lipid hydroperoxides, which has been discovered in recent years. Its regulatory mechanisms mainly involve iron metabolism, lipid peroxidation and amino acid metabolism. Ferroptosis is closely associated with the pathogenesis of ischemic stroke and is a promising therapeutic target for ischemic stroke. This article elaborates on the role of the main regulatory pathways of ferroptosis in ischemic stroke, providing new therapeutic ideas and targets for targeting the ferroptosis pathway to improve the outcome of ischemic stroke.
