Role of metabolic crosstalk between astrocytes and neurons in ischemic brain injury
10.3760/cma.j.issn.1673-4165.2023.09.012
- VernacularTitle:星形胶质细胞与神经元代谢互作在缺血性脑损伤中的作用
- Author:
Min SUN
1
;
Zibu WANG
;
Yun XU
;
Yanting CHEN
Author Information
1. 南京大学医学院附属鼓楼医院神经内科，南京 210008
- Keywords:
Ischemic stroke;
Astrocytes;
Neurons;
Glutamic acid;
Lactic acid;
Lipid metabolism
- From:
International Journal of Cerebrovascular Diseases
2023;31(9):703-710
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is a common cerebrovascular disease with high mortality and disability rates. Astrocytes, as the most abundant glial cells in the brain, have the function of maintaining the homeostasis of the central nervous system, which requires precise coupling between neurotransmission and energy metabolism. Therefore, the metabolic crosstalk between astrocytes and neurons plays an important role in the occurrence and development of ischemic stroke. On the one hand, ischemic stroke leads to neuronal excessive excitation, metabolic disorders, and even death, simultaneously promoting changes in astrocyte metabolism profile and increased heterogeneity. On the other hand, the metabolic crosstalk between astrocytes and neurons can also affect the outcome of ischemic stroke. This article reviews the role of the metabolic crosstalk between astrocytes and neurons in ischemic brain injury, and looks forward to potential research directions and treatment targets in the future, in order to provide theoretical reference for the treatment of ischemic stroke.
