Polarization shift of microglia phenotype: therapeutic targets for ischemic stroke
10.3760/cma.j.issn.1673-4165.2023.08.012
- VernacularTitle:小胶质细胞极化表型的转换：缺血性卒中的治疗靶点
- Author:
Jingru WANG
1
;
Jiayi YANG
;
Daojing LI
;
Gaomei CAI
Author Information
1. 济宁医学院临床医学院，济宁 272000
- Keywords:
Ischemic stroke;
Microglia;
Inflammation;
Immunity;
Phenotype;
Neuroprotection
- From:
International Journal of Cerebrovascular Diseases
2023;31(8):631-635
- CountryChina
- Language:Chinese
-
Abstract:
Neuroinflammatory response may accelerate tissue damage after ischemic stroke and affect neuronal death and neurogenesis. Microglia are an important line of defense against central nervous system injury, which are rapidly activated after cerebral ischemia and exert their effects by releasing various inflammatory mediators. Therefore, promoting the transition of microglia from M1 phenotype to M2 phenotype or maintaining dynamic balance between the two during the inflammatory process after ischemic stroke may be the important therapeutic targets for reducing inflammation after cerebral ischemia.
