Ischemic stroke model in large animals
10.3760/cma.j.issn.1673-4165.2023.06.012
- VernacularTitle:大动物缺血性卒中模型
- Author:
Xiaoduo HE
1
;
Jian CHEN
;
Longfei WU
;
Yuchuan DING
;
Di WU
Author Information
1. 首都医科大学宣武医院中美神经科学研究所，北京 100053
- Keywords:
Stroke;
Brain ischemia;
Disease models, animal;
Dogs;
Swine;
Sheep;
Primates
- From:
International Journal of Cerebrovascular Diseases
2023;31(6):467-471
- CountryChina
- Language:Chinese
-
Abstract:
Due to the failure of multiple translational researches, Stroke Therapy Academic Industry Roundtable (STAIR) recommends the use of large animal models of focal cerebral ischemia for preclinical researches. Especially, stroke treatment has currently entered a new era of vascular recanalization. Large animals commonly used in acute ischemic stroke models include dogs, swine, sheep, and non-human primates, which can be used to simulate various aspects of cerebral ischemia and reperfusion (vascular recanalization) in patients. Although large animals have significant advantages due to their proximity to humans in anatomy and physiology, there are also issues with anatomical and physiological specificity and ethical limitations. This article summarizes the large animal ischemic stroke models prepared by craniotomy and endovascular intervention, hoping to help researchers select the most appropriate large animal ischemic stroke model, and then promote the development of stroke translational research.
