Relationship of serum miR-137 and miR-21 expression with hypertensive retinopathy
10.3969/j.issn.1673-4130.2024.02.011
- VernacularTitle:血清miR-137、miR-21表达与高血压性视网膜病变的关系
- Author:
Aili ZHAO
1
;
Xiaojing CUI
Author Information
1. 廊坊市中医医院 眼科,河北廊坊 065000
- Keywords:
hypertension;
retinopathy;
microRNA-137;
microRNA-21;
predictive value
- From:
International Journal of Laboratory Medicine
2024;45(2):179-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum microRNA(miR)-137 and miR-21 ex-pression and hypertensive retinopathy(HR).Methods A total of 123 hypertensive patients admitted to the hospital from March 2020 to August 2022 were selected as the hypertensive group and divided into HR and non-HR groups according to whether they were concomitant with HR,and another 58 healthy people who un-derwent the physical examination during the same period were selected as the control group.Clinical data of HR patients were collected and serum miR-137 and miR-21 expression was detected by real-time fluorescent quantitative PCR.The influencing factors of concurrent HR in hypertensive patients were analyzed,and receiv-er operating characteristic(ROC)curve was used for analzing predictive value of serum miR-137 and miR-21 expression in hypertensive patients with concurrent HR.Results Serum miR-137 and miR-21 relative expres-sion levels were higher in the hypertensive group than those in the control group(P<0.05).The incidence rate of HR in 123 hypertensive patients was 25.20%(31/123).Multivariate Logistic regression analysis showed that prolonged duration of hypertension and elevated systolic pressure,diastolic pressure,miR-137 rel-ative expression level,and miR-21 relative expression level were independent risk factors for HR in hyperten-sive patients(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum miR-137 combined with miR-21 in predicting HR in hypertensive patients was 0.840,which was greater than 0.735 and 0.732 of the single detection of miR-137 and miR-21(P<0.05).Conclusion High expression of serum miR-137 and miR-21 is closely associated with hypertension complicating HR and may be an auxiliary predictor of HR.
