Progress on microRNA in Mycoplasma pneumoniae pneumonia in children

VernacularTitle:微小RNA在儿童肺炎支原体肺炎中的研究进展
Author: Ying NA ¹ ; Shaofei YU ; Hua ZHU
Author Information

1. 内蒙古自治区人民医院儿科，呼和浩特　010010
Keywords: Children; Mycoplasma pneumoniae; MicroRNA
From: International Journal of Pediatrics 2024;51(3):188-192
CountryChina
Language:Chinese
Abstract: Mycoplasma pneumoniae pneumonia（MPP）is a respiratory infectious diseases caused by Mycoplasma pneumoniae（MP）infection.It is one of the common community-acquired pneumonia in children. The pathogenesis of MPP may be related to the direct adhesion and damage of MP to the host and the disorder of immune response. At present，a large number of studies have confirmed that the immune disorder plays a vital role in the development of MPP. MicroRNA（miRNA）is a group of highly conserved non-protein-coding nucleotide sequences，involved in regulating the Th17/Treg ratio，nuclear factor-κB（NF-κB），CD4 +T/CD8 +T ratio，and Th1/Th2 ratio to play important roles in lung growth，inflammatory response and immune regulation during the pathogenesis of MPP. This article provides an overview of the mechanism of action of miRNAs in MPP，analyzes the potential connections between miRNAs and the development of MPP，and offers insights for the clinical assessment of children's condition and treatment plans.