Progress on gene polymorphism of allergic asthma
10.3760/cma.j.issn.1673-4408.2024.03.009
- VernacularTitle:过敏性哮喘基因多态性研究进展
- Author:
Zhiying GAO
1
;
Luofei CAO
;
Guangzeng MA
;
Yu MIAO
;
Yuting GENG
;
Jinrong WANG
Author Information
1. 山东中医药大学第二临床医学院,济南 250355
- Keywords:
Allergic asthma;
Gene polymorphism;
Dust mite;
Fungus
- From:
International Journal of Pediatrics
2024;51(3):183-187
- CountryChina
- Language:Chinese
-
Abstract:
Allergic asthma is a complex，polygenic disease characterized by chronic inflammation and airway hyperresponsiveness. Fungus and dust mites are the most important inhaled allergens of allergic asthma，and often exist in the form of mixed allergens. In recent years，genetic studies have shown that several genes are associated with allergic asthma attacks. This article reviews the studies on the genes related to allergic asthma caused by dust mites and fungus，such as a disintegrin and metalloproteinase 33（ADAM33），interleukin-4（IL-4），glycoprotein A repetitions predominant（GARP），toll like receptor 3（TLR3），mannose-binding lectin 2（MBL2），chemokine（C-C motif）ligand 17（CCL17）and other genes .
