Progress of biomarkers for the efficacy of allergen immunotherapy

VernacularTitle:变应原免疫治疗疗效相关生物标志物研究进展
Author: Xiya CHEN ¹ ; Jing HE ; Zhimin CHEN
Author Information

1. 浙江大学医学院附属儿童医院呼吸科　国家儿童健康与疾病临床医学研究中心，杭州310052
Keywords: Allergen immunotherapy; Allergic rhinitis; Asthma; Biomarker
From: International Journal of Pediatrics 2024;51(3):143-147
CountryChina
Language:Chinese
Abstract: Allergen immunotherapy（AIT）is currently the etiological treatment for respiratory allergic diseases，which can change the natural course of the disease.However，due to the complexity of patients' autoimmune status，allergy triggers and their complicated relationship with AIT vaccines，there are still about 40% of allergic rhinitis and 10%-20% of asthma patients who respond nonoptimally or even don't show any response to AIT. Thus，searching biomarkers that can evaluate and predict the efficacy of AIT and optimize the AIT strategy has been a major focus and challenge in allergy field.Currently，several serologic biomarkers have been found to be associated with AIT efficacy in vitro，but their value as predictive biomarkers of AIT efficacy needs to be further verified. This article reviews the research progress of serologic candidate biomarkers for AIT efficacy.