Advances in the role of prostaglandins in patent ductus arteriosus
10.3760/cma.j.issn.1673-4408.2024.02.004
- VernacularTitle:前列腺素在动脉导管未闭中的作用研究进展
- Author:
Xiaohang CHENG
1
;
Fan WANG
Author Information
1. 兰州大学第二医院新生儿科 730000
- Keywords:
Patent ductus arteriosus;
Prostaglandin;
Preterm infant;
Newborn
- From:
International Journal of Pediatrics
2024;51(2):86-89
- CountryChina
- Language:Chinese
-
Abstract:
The ductus arteriosus is an important lifeline for fetal circulation.Prostaglandins（PG）are involved in the dilatation of the ductus arteriosus during fetal life as well as the anatomical remodeling of the ductus arteriosus after birth. Patent ductus arteriosus（PDA）is a common congenital heart disease in preterm infants.The treatment by inhibiting local PG synthesis is currently the principal means of clinical practice，with indomethacin and ibuprofen being the most commonly applied drugs，but the prevalence of adverse effects has led scholars to focus on other targets of the PG synthesis pathway. This paper reviews relevant medications and combines the physiological effects of PG on ductus arteriosus in different stages to summarize the current drugs of treating PDA and their related research advances，with the aim to provide new strategies for the treatment and future research of this condition.
