Progress of LINGO-1 in neurological diseases
10.3760/cma.j.issn.1673-4408.2024.01.012
- VernacularTitle:LINGO-1在神经系统疾病中的研究进展
- Author:
Jiayi LIU
1
;
Hua ZHU
;
Xuewen SU
Author Information
1. 内蒙古科技大学包头医学院 014000
- Keywords:
Neurological diseases;
LINGO-1;
Axon regeneration;
Oligodendrocyte activation;
Inflammation
- From:
International Journal of Pediatrics
2024;51(1):59-63
- CountryChina
- Language:Chinese
-
Abstract:
LINGO-1，a Nogo receptor-interacting protein-1 rich in leucine repeat sequences and immunoglobulin structural domains，which is specifically expressed in neurological diseases. In recent years，more and more evidences indicate that LINGO-1 plays an important role in glial scar formation，cell death and inflammatory reaction. LINGO-1 inhibits oligodendrocyte activation，and prevents axon and myelin formation and functional recovery，and is therefore considered to be a negative regulator of neuronal survival，neurite extension and axon myelination. The change of LINGO-1 level is related to the occurrence and development of many neurological diseases. This article reviews the physiological function of LINGO-1 and summarizes the latest research progress of LINGO-1 in multiple sclerosis，spinal cord injury，neonatal brain injury and epilepsy，so as to explore new strategies for the treatment of neurological diseases.
