Progress of intestinal organoids in necrotizing enterocolitis
10.3760/cma.j.issn.1673-4408.2023.12.009
- VernacularTitle:肠道类器官在坏死性小肠结肠炎中的研究进展
- Author:
Qinlei YU
1
;
Xiangyun YAN
;
Shuping HAN
Author Information
1. 南京医科大学附属妇产医院 南京市妇幼保健院儿科 210004
- Keywords:
Organoids;
Somatic stem cells;
Necrotizing enterocolitis
- From:
International Journal of Pediatrics
2023;50(12):829-832
- CountryChina
- Language:Chinese
-
Abstract:
Necrotizing enterocolitis(NEC)is an acute intestinal inflammation characterized by mucosal edema, epithelial ischemic necrosis, and crypt destruction.The intestinal organoid 3D culture system derived from intestinal stem cells has been developed as a valuable research model for studying NEC in vitro.To fully understand the progression of NEC, it is crucial to comprehend the changes that take place in the intestinal stem cell niche, as well as the interactions among different cell types in the intestinal crypt.On the other hand, intestinal organoids can also be used directly for the treatment of NEC, and for screening of specific drugs or nutrients for NEC in vitro .This article provides a review of intestinal organoids and their recent advancements in NEC research.
