Progress of microglial efferocytosis in neonatal hypoxic ischemic encephalopathy
10.3760/cma.j.issn.1673-4408.2023.12.006
- VernacularTitle:小胶质细胞胞葬作用在新生儿缺氧缺血性脑病中的研究进展
- Author:
Wenqi LI
1
;
Jie QIU
Author Information
1. 南京医科大学 210029
- Keywords:
Neonate;
Hypoxic ischemic encephalopathy;
Microglia;
Efferocytosis
- From:
International Journal of Pediatrics
2023;50(12):815-819
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal hypoxic ischemic encephalopathy(HIE)is a hypoxic ischemic brain injury caused by perinatal asphyxia.It is the major cause of neonatal death and neurological damage of infant and children, and its characteristic pathophysiological alteration is massive neuronal apoptosis.Microglia, one of the central nervous system phagocytes, play an important role in development of neonatal HIE.In recent years, efferocytosis has been discovered to be a specific phagocytosis of phagocytes.In neonatal HIE, microglia are able to remove apoptotic cells through efferocytosis, preventing further necrosis of apoptotic cells, which can trigger inflammatory responses and brain damage.Understanding the role of microglial efferocytosis in neonatal HIE may aid in elucidating its pathogenesis and exploring potential therapeutic approaches.This article is a review of the progress of microglial efferocytosis in neonatal HIE.
