Advances in prognostic indicators of juvenile myelomonocytic leukemia
10.3760/cma.j.issn.1673-4408.2023.12.005
- VernacularTitle:幼年型粒单核细胞白血病预后指标研究进展
- Author:
Chenmeng LIU
1
;
Wenyu YANG
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所） 实验血液学国家重点实验室 国家血液系统疾病临床医学研究中心 细胞生态海河实验室，天津 300020
- Keywords:
Children;
Juvenile myelomonocytic leukemia;
Prognostic factor
- From:
International Journal of Pediatrics
2023;50(12):810-814
- CountryChina
- Language:Chinese
-
Abstract:
Juvenile myelomonocytic leukemia(JMML)is a rare hematopoietic malignant disease that occurs mostly in infants and young children.JMML is clinically heterogeneous, with most patients having rapid progression and a poor prognosis.A minority of patients have slow progression and may achieve spontaneous remission.Indicators affecting the prognosis of patients include clinical features, hematologic indicators, genetic mutations, acute myeloid leukemia-like gene expression profiles, and epigenetic alterations.Finding JMML prognostic indicators for risk grouping is of great significance for prognostic assessment and individualized therapy.This paper aims to review the advances in prognostic indicators of JMML.
