Advances in genetics of IgA vasculitis
10.3760/cma.j.issn.1673-4408.2023.11.012
- VernacularTitle:IgA血管炎相关遗传学研究进展
- Author:
Hui WANG
1
;
Yuhong LI
;
Xiaoshan SHAO
Author Information
1. 贵州医科大学临床医学院，贵阳 550004
- Keywords:
IgA vasculitis;
Henoch-Sch?nlein purpura nephritis;
Genetics
- From:
International Journal of Pediatrics
2023;50(11):768-772
- CountryChina
- Language:Chinese
-
Abstract:
IgA vasculitis(IgAV)is a systemic vasculitis characterized mainly by deposits of IgA, which can involve multiple systems such as skin, joints, digestive tract and kidney.When the kidney is damaged, it is often called Henoch-Sch?nlein purpura nephritis, which is a common secondary glomerulonephritis in children.The specific etiology and pathogenesis of IgAV have not been very clear so far, and further studies are needed.With the development of genomics, the researchers continue to study IgAV from the gene level, and realize that HLA is the most important genetic factor in its pathogenesis.In recent years, related genetic research methods have been extended to genome-wide association studies, and the occurrence and development process of IgAV has been analyzed from the epigenetic aspect.This article reviews advances in genetics of IgAV, which will provide important information for understanding the pathogenesis of IgAV and predicting the occurrence of high-risk individuals, disease severity and kidney damage.
