Advances in cytokines in systemic juvenile idiopathic arthritis
10.3760/cma.j.issn.1673-4408.2023.11.011
- VernacularTitle:细胞因子与全身型幼年特发性关节炎的研究进展
- Author:
Jiatao WANG
1
;
Yanming LU
Author Information
1. 上海交通大学医学院附属仁济医院儿科 201112
- Keywords:
Systemic juvenile idiopathic arthritis;
Macrophage activation syndrome;
Cytokines
- From:
International Journal of Pediatrics
2023;50(11):763-767
- CountryChina
- Language:Chinese
-
Abstract:
With the development of economy and medicine, chronic diseases have become a more and more prominent problem affecting children′s physical and mental development.Juvenile idiopathic arthritis(JIA)is a common rheumatic disease in children.As an important medium of immune response, cytokines play a role in systemic juvenile idiopathic arthritis(SJIA)and its complication such as macrophage activation syndrome(MAS), which has attracted more and more attention.Many studies have found that a variety of cytokines play an inflammatory or anti-inflammatory role in the occurrence and development of SJIA and MAS.Therefore, this paper summarizes the specific mechanism of action and clinical significance of related cytokines in SJIA and MAS, and reviews the progress of related drug therapy targeting cytokines.By exploring the pathogenesis of SJIA, we hope to provide theoretical basis for identifying new therapeutic targets.
