Rapid Screening of 34 Emerging Contaminants in Surface Water by UHPLC-Q-TOF-MS
10.12116/j.issn.1004-5619.2022.320301
- VernacularTitle:地表水中34种新兴污染物的超高效液相色谱-四极杆-飞行时间质谱快速筛查
- Author:
Chen-Shan LÜ
1
,
2
,
3
;
Yi-Xuan CAO
;
Xiao-Xi MU
;
Hai-Yan CUI
;
Tao WANG
;
Zhi-Wen WEI
;
Ke-Ming YUN
;
Meng HU
Author Information
1. 山西医科大学法医学院,山西 晋中 030600
2. 法医学山西省重点实验室,山西 晋中 030600
3. 法庭毒物分析公安部重点实验室,山西 晋中 030600
- Keywords:
forensic medicine;
toxicology;
solid phase extraction;
ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry;
surface water;
emerging contaminants
- From:
Journal of Forensic Medicine
2024;40(1):30-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a rapid screening method for 34 emerging contaminants in surface water by ultra-high performance liquid chromatography-quadrupole-time of flight mass spectrometry(UHPLC-Q-TOF-MS).Methods The pretreatment conditions of solid phase extraction(SPE)were op-timized by orthogonal experimental design and the surface water samples were concentrated and ex-tracted by Oasis? HLB and Oasis? MCX SPE columns in series.The extracts were separated by Kine-tex? EVO C18 column,with gradient elution of 0.1%formic acid aqueous solution and 0.1%formic acid methanol solution.Q-TOF-MS'fullscan'and'targeted MS/MS'modes were used to detect 34 emerging contaminants and to establish a database with 34 emerging contaminants precursor ion,prod-uct ion and retention times.Results The 34 emerging contaminants exhibited good linearity in the con-centration range respectively and the correlation coefficients(r)were higher than 0.97.The limit of de-tection was 0.2-10 ng/L and the recoveries were 81.2%-119.2%.The intra-day precision was 0.78%-18.70%.The method was applied to analyze multiple surface water samples and 6 emerging contaminants were detected,with a concentration range of 1.93-157.71 ng/L.Conclusion The method is simple and rapid for screening various emerging contaminants at the trace level in surface water.
