Effects of sublingual immunotherapy on Treg/Th17 cell balance and related cytokines in preschool children aged 3-6 years with allergic rhinitis
10.16066/j.1672-7002.2024.01.008
- VernacularTitle:舌下免疫治疗对3～6岁学龄前儿童变应性鼻炎Treg/Th17细胞平衡及相关细胞因子的影响
- Author:
Zebin JIANG
1
;
Zeming MA
;
Danjie WANG
Author Information
1. 普宁市人民医院耳鼻咽喉科,广东 普宁 515300
- Keywords:
Immunotherapy;
Administration,Sublingual;
Child;
Rhinitis,Allergic;
T-Lymphocytes,Regulatory;
Th17 Cells;
Cytokines;
Sublingual immunotherapy
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2024;31(1):36-40
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the impact of sublingual immunotherapy(SLIT)on the balance of Treg/Th17 cells and related cytokines in preschool children aged 3-6 years with allergic rhinitis(AR).METHODS Seventy preschool children aged 3-6 years with AR were divided into the SLIT group and the medication group,and their clinical data were retrospectively analyzed.The medication group received symptomatic treatment alone,while the SLIT group received a combined treatment of SLIT and symptomatic medication,with a 3-year follow-up period.The Treg/Th17 cell balance,serum levels of TGF-β,IL-10,IL-17,IL-21,as well as the total nasal symptom score(TNSS),total medication score(TMS),and visual analog scale(VAS)scores were compared before and after treatment between the two groups.RESULTS After 3 years of treatment,both groups showed significant improvements(P<0.05)in the percentages of CD4+CD25+Foxp3+Treg and CD4+IL-17+Th17 cells among CD4+T cells,percentages of Treg and Th17 cells,serum levels of TGF-β,IL-10,IL-17,IL-21,TNSS,TMS,and VAS scores.Moreover,the SLIT group exhibited significantly better outcomes compared to the medication group(P<0.05).CONCLUSION SLIT can modulate the balance of Treg/Th17 cells and improve serum levels of TGF-β,IL-10,IL-17,and IL-21.
