Research progress of Lactobacillus and intestinal mechanical barrier
10.16151/j.1007-810x.2023.05.011
- VernacularTitle:乳杆菌与肠道机械屏障的研究进展
- Author:
Long-Chang HUANG
1
;
Peng WANG
;
Xin-Ying WANG
Author Information
1. 南京大学医学院附属金陵医院/东部战区总医院全军普通外科研究所,江苏南京 210002
- Keywords:
Gut;
Lactobacillus;
Mechanical barrier
- From:
Parenteral & Enteral Nutrition
2023;30(5):315-320
- CountryChina
- Language:Chinese
-
Abstract:
The intestinal mechanical barrier is the first line of defense against intestinal bacteria,and its damage can lead to a variety of diseases.Lactobacillus,as a probiotic with clinical application prospect,can stimulate the proliferation and differentiation of intestinal epithelial cells,reduce the death of intestinal epithelial cells,enhance the connectivity between intestinal epithelial cells,and promote mucin secretion and improve and maintain the mechanical barrier of intestinal tract.This article reviews the role and mechanism of Lactobacillus in protecting the intestinal mechanical barrier,aiming to deepen the understanding of Lactobacillus,explore its prevention and treatment of intestinal diseases in future clinical practice,and inspire new microbial strategies for the clinical application of Lactobacillus and its products.
