Research progress of microRNA-126 in cardiovascular diseases

VernacularTitle:微小RNA-126在心血管疾病中的研究进展
Author: Aihemaiti ABULAJIANG ¹ ; Yiping MA ; Nijiati MUYESAI
Author Information

1. 新疆医科大学研究生院,乌鲁木齐 830017
Keywords: microRNA-126; myocardial cells; cardiovascular disease; review
From: Chongqing Medicine 2024;53(5):772-776,781
CountryChina
Language:Chinese
Abstract: Cardiovascular disease(CVD)is a major cause of human death and a serious threat to people's health.Therefore,it is very important to explore the early identification,diagnosis and effective treat-ment of CVD.The expression level of microRNA(miRNA)is related to many pathophysiological processes related to CVD,such as myocardial cell metabolism disorder,myocardial cell injury and myocardial fibrosis,which makes miRNA an important entry point for the diagnosis and treatment of CVD.MicroRNA-126(miR-126)is one of the most important biological markers in the miRNA family.It plays a role in protecting the myocardium by participating in angiogenesis,endothelial cell repair,and inhibition of inflammatory responses.This article reviewed the latest research progress on the mechanism,diagnostic significance and potential ther-apeutic value of miR-126 in the occurrence and development of various types of CVD.