Study on the therapeutic effect of Xuefu Zhuyu Capsule combined with sacubitril valsartan on patients with dilated cardiomyopathy
10.3969/j.issn.1671-8348.2024.04.007
- VernacularTitle:血府逐瘀胶囊联合沙库巴曲缬沙坦对扩张型心肌病的治疗效果研究
- Author:
Zhenhuan CHEN
1
;
Yuan LIU
;
Xiantao HUANG
;
Yanfeng LIU
;
Yu TAO
;
Hengli LAI
;
Qiuling LIU
Author Information
1. 江西省人民医院/南昌医学院第一附属医院心内科,南昌 330000
- Keywords:
xuefu zhuyu capsule;
sacubitril valsartan;
dilated cardiomyopathy;
n-terminal pro-brain na-triuretic peptide;
efficacy
- From:
Chongqing Medicine
2024;53(4):512-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutic effect of Xuefu Zhuyu Capsule combined with sacubitril valsartan on dilated cardiomyopathy.Methods A total of 70 patients with dilated cardiomyopathy who were hospitalized in the Hospital from January to December 2020 were selected as the research objects and random-ly divided into control group and experimental group,with 35 cases in each group.The control group was only treated with sacubitril valsartan,and the experimental group was treated with Xuefu Zhuyu Capsule combined with sacubitril valsartan.According to the patient's blood pressure and renal function,sacubitril valsartan was titrated from a small dose to the maximum dose.Xuefu Zhuyu Capsule was uesd 2.4 g each time,twice a day,and the treatment time was three months.The symptoms of heart failure,glycosylated hemoglobin(HbA1c),low density lipoprotein(LDL),total cholesterol(TC),triglyceride(TG),ALT,AST,N-terminal pro-brain natriuretic peptide(NT-proBNP),left ventricular end-systolic diameter(LVEDd),left ventricular end-dias-tolic diameter(LVEDs),ejection fraction(EF)and the incidence of arrhythmia were observed in the two groups after treatment.Results After treatment,the level of NT-proBNP in the experimental group was sig-nificantly lower than that in the control group(P＜0.05).There was no significant difference in LDL,TC,TG,LVEDd,LVEDs and EF between the two groups(P＞0.05).The incidence of atrial tachycardia and ven-tricular premature beat in the experimental group was higher than that in the control group(P＜0.05).Con-clusion Xuefu Zhuyu Capsule combined with sacubitril valsartan can significantly improve the symptoms of patients with heart failure and reduce the level of NT-proBNP,but it may increase the proportion of patients with atrial tachycardia and ventricular premature beats.
