Clinical characteristics of children patients with carbapenem resistant Klebsiella pneumoniae infection and risk factors for poor prognosis
10.3969/j.issn.1671-8348.2024.02.008
- VernacularTitle:儿童CRKP感染的临床特征及预后不良危险因素研究
- Author:
Chunyun FU
1
;
Huan ZHANG
;
Minxue LIU
;
Zhenjiao CEN
;
Jialing RUAN
;
Shuangjie WANG
;
Xuehua HU
Author Information
1. 广西壮族自治区妇幼保健院医学检验科,南宁 530003
- Keywords:
carbapenem resistant Klebsiella pneumoniae;
drug resistance;
risk factors;
multiple organ dysfunction;
anemia
- From:
Chongqing Medicine
2024;53(2):198-203
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics,drug resistance and risk factors for poor prognosis in children patients with carbapenem resistant Klebsiella pneumoniae(CRKP)infection.Methods The samples of CRKP isolated from the children inpatients in this hospital from August 5,2016 to December 31,2020 were collected.The clinical data and drug resistance of CRKP in the patients with CRKP positive were analyzed.The risk factors in the poor prognosis group and good prognosis group of children pa-tients with CRKP infection conducted the correlation analysis.Results A total of 106 strains of non-repeti-tive CRKP were collected,which were mainly isolated from the patients ≤ 1 year old.The department distri-bution was dominated by the neonatal ICU and comprehensive ICU.CRKP showed the high resistance to mul-tiple antibacterial drugs,and its resistance rates to amikacin,levofloxacin,gentamicin,ciprofloxacin,minocy-cline and chloramphenicol were less than 30％.The poor prognosis rate in the children patients with CRKP in-fection reached 27.4％.The logistic multivariate regression analysis results showed that the multiple organ dysfunction and anemia were the independent risk factors for poor prognosis in the children patients with CRKP infection(P＜0.05).Conclusion The children CRKP infection is mainly the infants ≤1 years old,and CRKP shows the high resistance to multiple antibacterial drugs,the independent risk factors of poor prognosis include the multiple organ dysfunction and anemia
