Effects of dexmedetomidine on activation of mast cells around hematoma and neurological impairment in mouse intracerebral hemorrhage
10.3969/j.issn.1671-8348.2024.02.003
- VernacularTitle:右美托咪定对脑出血小鼠肥大细胞激活及神经功能损伤的影响
- Author:
Zhengyu YANG
1
;
Qingxiang MAO
Author Information
1. 陆军军医大学大坪医院麻醉科,重庆 400042
- Keywords:
dexmedetomidine;
intracerebral hemorrhage;
mast cell;
neurological function
- From:
Chongqing Medicine
2024;53(2):171-175
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of dexmedetomidine on the neurological function and mast cells activation in the mouse with intracerebral hemorrhage(ICH).Methods The mouse was intraperitoneal-ly injected with dexmedetomidine at 30 min before intracerebral hemorrhage.After the preparation of intrace-rebral hemorrhage model,the neurological function,brain water content,number of mast cells around hemato-ma and expression levels of tryptase,IL-1β,TNF-α were detected.Results Compared with the control group,the neurological function score in the intracerebral hemorrhage group was significantly elevated(P＜0.05),the brain water content was significantly increased(P＜0.05),the mast cells number was significantly in-creased(P＜0.05),and the tryptase,IL-1β and TNF-α expression levels were sinificantly increased(P＜0.05);while the neurological function score in the dexmedetomidine group was significantly decreased(P＜0.05),the brain water content was significantly decreased(P＜0.05),the number of mast cells was signifi-cantly reduced and the tryptase,IL-1β and TNF-α expression levels were significantly decreased(P＜0.05).Conclusion Dexmedetomidine could inhibit the activation of mast cells around hematoma and reduce the dam-age of neurological function after mouse intracerebral hemorrhage.
